39th Int. Conf. on Infrared, Millimeter, and THz Waves
September 14-19, 2014
The University of Arizona, Tucson, AZ
M4/D - 8. Biology and Medical Applications II
Monday, September 15, 2014 4:00 pm to 5:30 pm
Room: Rincon Room
Chairperson: Emma MacPherson
4:00 pm 4:00 pm : Measurements And Calculations Of Protein Intramolecular Vibrations In The THz Range
Presenter: Katherine A. Niessen

We report the calculations and measurements of intramolecular vibrational modes and their dependence on inhibitor binding in the THz range. We see an increase in anisotropic THz absorption at low frequency with inhibitor binding in both the measurements and calculations. This surprising result suggests an increase in flexibility with binding. We will discuss the possible reasons for this discrepancy.

Author(s):
Katherine A. Niessen - University at Buffalo, SUNY
Edward Snell - Hauptman-Woodward Medical Research Institute
A. G. Markelz - University at Buffalo, SUNY
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4:30 pm 4:30 pm : An Investigation Of THz Burn Wound Edema Imaging Using MRI
Presenter: Neha Bajwa

Terahertz (THz) detection has been proposed and applied to a variety of medical imaging applications in view of its unrivaled hydration profiling capabilities. Variations in tissue dielectric function have been demonstrated at THz frequencies to generate high contrast imagery of burn tissue, however, the pathological basis of these THz tissue water content (TWC) maps remains to be verified using a modality with a comparable sensing scheme. To investigate edematous responses in THz wound imaging, a pilot comparison study in a burn wound rat model, widely known to create detectable gradients in tissue hydration through both injured and surrounding tissue, was performed. Parallel T2 weighted multi slice multi echo (T2w MSME) 7T Magnetic Resonance (MR) scans and THz surface reflectance maps were acquired of a full thickness skin burn in a rat model over a 5 hour time period. A comparison of uninjured and injured regions in the full thickness burn demonstrates a 3-fold increase in T2 relaxation times and 15% increase in average THz reflectivity, respectively. These results support the sensitivity and specificity of MRI for measuring burn tissue water content in vivo and the use of this modality to verify and understand the hydration sensing capabilities of THz imaging for acute assessments of the onset and evolution of diseases that affect the skin.

Author(s):
Neha Bajwa - UCLA Department of Bioengineering
Bryan Nowroozi - UCLA Department of Bioengineering
James Garritano - UCLA Department of Bioengineering
Shijun Sung - UCLA Department of Bioengineering
Priyamvada Tewari - UCLA Department of Bioengineering
Warren Grundfest - UCLA Department of Bioengineering
Zachary Taylor - UCLA Department of Bioengineering
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4:45 pm 4:45 pm : Excitation Of Low Loss HE11 Modes On An Acupuncture-Like Needle
Presenter: Gerard Rankin

In previous work, we have studied thermal and behavioral effects and the detection of termites by millimeter waves. Motivated by the intriguing possibilities of millimeter wave -- cellular, and higher level, biological interactions, we have investigated the design of an acupuncture-like needle for efficient delivery of millimeter waves through the skin. Contrary to conventional knowledge, a bare conductor can sustain two dominant modes: the well-known symmetric TM01 mode, and the hitherto overlooked asymmetrical HE11 mode. Here, we present a convertor for the excitation of the HE11 mode on a conductor.

Author(s):
Gerard Rankin - University of Adelaide
Andrew Tirkel - Scientific Technology
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5:00 pm 5:00 pm : Monitoring The Water Status Of Plants Using THz Radiation
Presenter: Norman Born

The high absorption coefficient of liquid water in the THz regime makes THz systems an excellent tool to perform in-vivo measurements in biological tissue regarding drought stress experiments. For real applications there are different approaches to obtain such measurements, which are discussed herein.

Author(s):
Norman Born - Philipps-University Marburg
Ralf Gente - Philipps-University Marburg
David Behringer - Philipps-University Marburg
Michael Schwerdtfeger - Philipps-University Marburg
Stefan Busch - Philipps-University Marburg
Sascha Liepelt - Philipps-University Marburg
Birgit Ziegenhagen - Philipps-University Marburg
Martin Koch - Philipps-University Marburg
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5:15 pm 5:15 pm : Morphological Study Of Sweat Ducts For The Investigation Of Terahertz Waves Interaction With Human Skin
Presenter: Saroj Tripathi

Recently it was reported that human sweat ducts play an important role in THz-skin interaction. Further understanding of such effects requires to know the morphological features of these ducts. Here, we analyzed the density and dimension of the ducts based on 3D images obtained with optical coherence tomography. We observed that the ducts possess helical structure and the diameter of the ducts from different regions of the body show considerable resemblance. Based on this information, we numerically determined the resonating frequency of helical ducts in axial mode of operation which resulted in the terahertz frequency region spanning from 0.3 THz to 0.6 THz.

Author(s):
Saroj Tripathi - Nagoya University
Eisuke Miyata - Nagoya University
Haruhito Yamada - Nagoya University
Kodo Kawase - Nagoya University
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